He made his debut in 2002 in the Malayalam film Nandanam, and has since acted in more than sixty films, notably Stop Violence (2002), Swapnakoodu (2003), Akale (2004), Classmates (2006), Vaasthavam (2006), Chocolate (2007), Thirakkatha (2008), Urumi (2011) and Indian Rupee (2011). He won the Kerala State Film Award for Best Actor for his performance in Vaasthavam.
Prithviraj made his debut in Tamil cinema through Kana Kandaen in 2005. His other notable films in Tamil are Parijatham (2005), Mozhi (2007) and Mani Ratnam’s Raavanan (2010).
As a producer he started his production company, August Cinema, along with Santosh Sivan and Shaji Natesan. August cinema has produced the films Urumi and Indian Rupee.